- قطر جينوم: رؤى حول علم الجينوم من الشرق الأوسط
Mbarek, H., Devadoss Gandhi, G., Selvaraj, S., Al-Muftah, W., Badji, R., Al-Sarraj, Y., Saad, C., Darwish, D., Alvi, M., Fadl, T., Yasin, H., Alkuwari, F., Razali, R., Aamer, W., Abbaszadeh, F., Ahmed, I., Mokrab, Y., Suhre, K., Albagha, O., Fakhro, K., … Althani, A. Human mutation, 10.1002/humu.24336. Advance online publication.
2022 Feb 02
https://doi.org/10.1002/humu.24336
- Genetic predisposition to porto-sinusoidal vascular disorder: A functional genomic-based, multigenerational family study.
Shan J, Megarbane A, Chouchane A, Karthik D, Temanni R, Reyes Romero A, Hua H, Pan C, Chen X, Subramanian M, Saad C, Mbarek H, Mehawej C, Chouery E, Abuaqel SW, Dömling A, Remadi S, Yaghi C, Li P, Chouchane L. Hepatology.
2022 Aug 21
DOI: 10.1002/hep.32735
- Ratios of Acetaminophen Metabolites Identify New Loci of Pharmacogenetic Relevance in a Genome-Wide Association Study.
Thareja G, Evans AM, Wood SD, Stephan N, Zaghlool S, Halama A, Kastenmüller G, Belkadi A, Albagha OME, The Qatar Genome Program Research Consortium, Suhre K. Metabolites. 12(6):496.
2022 May 30
https://doi.org/10.3390/metabo12060496
- The Spectrum of Genetic Variants Associated with the Development of Monogenic Obesity in Qatar.
AbouHashem, N., Zaied, R. E., Al-Shafai, K., Nofal, M., Syed, N., & Al-Shafai, M. Obesity facts, 10.1159/000521851. Advance online publication.
2022 May
https://doi.org/10.1159/000521851
- Analysis of incidental findings in Qatar genome participants reveals novel functional variants in LMNA and DSP.
Elfatih A, Da'as SI, Abdelrahman D, Mbarek H, Mohammed I, Hasan W, Fakhro KA, Estivill X, Mifsud B; Qatar Genome Program Research Consortium. Hum Mol Genet. ddac073.
2022 Mar 26
DOI: 10.1093/hmg/ddac073
- Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients.
Alkowari M, Espino-Guarch M, Daas S, Abdelrahman D, Hasan W, Krishnamoorthy N, Sathappan A, Sheehan P, Panhuys NV, The Qatar Genome Program Research Consortium, Estivill X. Int J Mol Sci.23(6):3369.
2022 Mar 21
https://doi.org/10.3390/ijms23063369
- A population study of clinically actionable genetic variation affecting drug response from the Middle East.
Jithesh, P. V., Abuhaliqa, M., Syed, N., Ahmed, I., El Anbari, M., Bastaki, K., Sherif, S., Umlai, U. K., Jan, Z., Gandhi, G., Manickam, C., Selvaraj, S., George, C., Bangarusamy, D., Abdel-Latif, R., Al-Shafai, M., Tatari-Calderone, Z., Estivill, X., Pirmohamed, M., & Qatar Genome Program Research Consortium. NPJ genomic medicine, 7(1), 10.
2022 Feb 15
https://doi.org/10.1038/s41525-022-00281-5
- Genetic predisposition to cancer across people of different ancestries in Qatar: a population-based, cohort study.
Saad, M., Mokrab, Y., Halabi, N., Shan, J., Razali, R., Kunji, K., Syed, N., Temanni, R., Subramanian, M., Ceccarelli, M., Qatar Genome Programme Research Consortium, Rafii Tabrizi, A., Bedognetti, D., & Chouchane, L. The Lancet. Oncology, S1470-2045(21)00752-X. Advance online publication.
2022 Feb 09
https://doi.org/10.1016/S1470-2045(21)00752-X
- Metabolic and Metabo-Clinical Signatures of Type 2 Diabetes, Obesity, Retinopathy, and Dyslipidemia.
Yousri, N. A., Suhre, K., Yassin, E., Al-Shakaki, A., Robay, A., Elshafei, M., Chidiac, O., Hunt, S. C., Crystal, R. G., & Fakhro, K. A. Diabetes, 71(2), 184–205.
2022 February
https://doi.org/10.2337/db21-0490
- The QChip1 knowledgebase and microarray for precision medicine in Qatar.
Rodriguez-Flores, J. L., Messai-Badji, R., Robay, A., Temanni, R., Syed, N., Markovic, M., Al-Khayat, E., Qafoud, F., Nawaz, Z., Badii, R., Al-Sarraj, Y., Mbarek, H., Al-Muftah, W., Alvi, M., Rostami, M. R., Cruzado, J., Mezey, J. G., Shakaki, A. A., Malek, J. A., Greenblatt, M. B., … Crystal, R. G. NPJ genomic medicine, 7(1), 3.
2022 Jan 19
https://doi.org/10.1038/s41525-021-00270-0
- Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Fallerini, C., Picchiotti, N., Baldassarri, M., Zguro, K., Daga, S., Fava, F., Benetti, E., Amitrano, S., Bruttini, M., Palmieri, M., Croci, S., Lista, M., Beligni, G., Valentino, F., Meloni, I., Tanfoni, M., Minnai, F., Colombo, F., Cabri, E., Fratelli, M., … Furini, S. (2022). Human genetics, 141(1), 147–173.
2021 Dec 10
https://doi.org/10.1007/s00439-021-02397-7
- One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar.
Benslimane, F. M., Al Khatib, H. A., Al-Jamal, O., Albatesh, D., Boughattas, S., Ahmed, A. A., Bensaad, M., Younuskunju, S., Mohamoud, Y. A., Al Badr, M., Mohamed, A. A., El-Kahlout, R. A., Al-Hamad, T., Elgakhlab, D., Al-Kuwari, F. H., Saad, C., Jeremijenko, A., Al-Khal, A., Al-Maslamani, M. A., Bertollini, R., … Yassine, H. M. Frontiers in cellular and infection microbiology, 11, 768883.
2021 Nov 17
https://doi.org/10.3389/fcimb.2021.768883
- Thousands of Qatari Genomes inform Human migration history and improve imputation of Arab haplotypes.
Razali RM, Rodriguez-Flores J, Ghorbani M, Naeem H, Aamer W, Aliyev E, Jubran A; Qatar Genome Program Research Consortium, Clark AG, Fakhro KA, Mokrab Y.. Nat Commun.
2021 Oct 12
12(1):5929. doi: 10.1038/s41467-021-25287-y. PMID: 34642339.
- Seven novel glucose-6-phosphate dehydrogenase (G6PD) deficiency variants identified in the Qatari population.
Malik S, Zaied R, Syed N, Jithesh P, Al-Shafai M. Hum Genomics.
2021 Oct 7
15(1):61. doi:10.1186/s40246-021-00358-9 PMID: 34620237; PMCID: PMC8499492.
- Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar.
Chemaitelly H, Tang P, Hasan MR, AlMukdad S, Yassine HM, Benslimane FM, Al Khatib HA, Coyle P, Ayoub HH, Al Kanaani Z, Al Kuwari E, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul Rahim HF, Nasrallah GK, Al Kuwari MG, Al Romaihi HE, Butt AA, Al-Thani MH, Al Khal A, Bertollini R, Abu-Raddad LJ. N Engl J Med.
2021 Oct 6
doi:10.1056/NEJMoa2114114. Epub ahead of print. PMID: 34614327.
- Poking COVID-19: insights on genomic constraints among immune-related genes between Qatari and Italian populations.
Hamdi Mbarek, Massimiliano Cocca, Yasser Al Sarraj, Chadi Saad, Massimo Mezzavilla, Wadha AlMuftah, Dario Cocciadiferro, Antonio Novelli, Isabella Quinti, Azza AlTawashi, Salvino Salvaggio, Asma AlThani, Giuseppe Novelli, Said Ismail medRxiv
2021 Oct 04
21264507; doi: 10.1101/2021.10.04.21264507
- Actionable genomic variants in 6045 participants from the Qatar Genome Program.
Elfatih A, Mifsud B, Syed N, Badii R, Mbarek H, Abbaszadeh F; Qatar Genome Program Research Consortium, Estivill X. Hum Mutat.
2021 August 24
- Mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative. Nature, 600(7889), 472–477.
2021 July 08
https://doi.org/10.1038/s41586-021-03767-x
- Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants.
Abu-Raddad LJ, Chemaitelly H, Butt AA; National Study Group for COVID-19 Vaccination. N Engl J Med.:NEJMc2104974. Epub ahead of print. PMID: 33951357; PMCID: PMC8117967.
2021 July 08
- Associations of Vaccination and of Prior Infection With Positive PCR Test Results for SARS-CoV-2 in Airline Passengers Arriving in Qatar.
Bertollini R, Chemaitelly H, Yassine HM, Al-Thani MH, Al-Khal A, Abu-Raddad LJ. JAMA. Epub ahead of print. PMID: 34106201.
2021 Jun 9
- Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19.
J Clin Invest.147834. Epub ahead of print. PMID: 34043590.
2021 May 27
- WHOLE GENOME SEQUENCING OF A MIDDLE EASTERN COHORT REPLICATES KNOWN LOCI FOR CORONARY HEART DISEASE AND IDENTIFIES POTENTIAL NOVEL ONES.
Khalid Kunji, Ayman El-Menyar, Ehsan Ullah, Iftikhar Kullo, Mohamad Saad, Jassim Al Suwaidi, Journal of the American College of Cardiology, Volume 77, Issue 18, Supplement 1, Page 13, ISSN 0735-1097.
2021 May 03
doi.org/10.1016/S0735-1097(21)01372-3
- SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy.
Abu-Raddad LJ, Chemaitelly H, Coyle P, Malek JA, Ahmed AA, Mohamoud YA, Younuskunju S, Ayoub HH, Al Kanaani Z, Al Kuwari E, Butt AA, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul Rahim HF, Nasrallah GK, Yassine HM, Al Kuwari MG, Al Romaihi HE, Al-Thani MH, Al Khal A, Bertollini R. EClinicalMedicine. 2021 May;35:100861. Epub. PMID: 33937733; PMCID: PMC8079668
2021 Apr 27
doi: 10.1016/j.eclinm.2021.100861
- Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits.
Albagha O, Suhre K, Qatar Genome Program Research (QGPR) Consortium, et al.Nature Communications
2021 Feb 23
https://doi.org/10.1038/s41467-021-21381-3
- Distinct antibody repertoires against endemic human coronaviruses in children and adults.
Khan T, Rahman M, Ali FA, Huang SSY, Ata M, Zhang Q, Bastard P, Liu Z, Jouanguy E, Béziat V, Cobat A, Nasrallah GK, Yassine HM, Smatti MK, Saeed A, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Meyts I, Abel L, Casanova JL, Hasan MR, Marr N. JCI Insight.;6(4):e144499. PMID: 33497357; PMCID: PMC7934927
2021 Jan 26
doi: 10.1172/jci.insight.144499
- Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank.
Rossi N, Aliyev E, Visconti A, Akil ASA, Syed N, Aamer W, Padmajeya SS, Falchi M, Fakhro KA.NPJ Genom Med.;6(1):8. PMID: 33563995; PMCID: PMC7873199.
2021 Feb 9
doi: 10.1038/s41525-021-00170-3
- THE FUTURE OF MEDICINE, Healthcare Innovation through Precision Medicine: Policy Case Study of Qatar.
Qoronfleh MW, Chouchane L, Mifsud B, Al Emadi M, Ismail S. Life Sci Soc Policy.16(1):12.
2020 Nov 1
doi: 10.1186/s40504-020-00107-1
- Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis.
Smatti Maria K., Al-Sarraj Yasser A., Albagha Omar, Yassine Hadi M. Front. Genet. 11:578523.
2020 Oct 02
https://doi.org/10.3389/fgene.2020.578523
- Willingness to participate in genome testing: a survey of public attitudes from Qatar.
Abdul Rahim, H.F., Ismail, S.I., Hassan, A. et al. J Hum Genet.
2020 July 28
https://doi.org/10.1038/s10038-020-0806-y
- Islamic Perspectives on CRISPR/Cas9-Mediated Human Germline Gene Editing: A Preliminary Discussion.
Isa NM, Zulkifli NA, Man S.Sci Eng Ethics. 2020 Feb;26(1):309-323. Epub. PMID: 30830592.
2019 Mar 4
doi: 10.1007/s11948-019-00098-z
- RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis.
Sastry KS, Naeem H, Mokrab Y, Chouchane AI. Oxid Med Cell Longev.2019:2841814. PMID: 31871544; PMCID: PMC6913168.
2019 Dec 4